XCaliber Health, a developer of an agentic operating system purpose-built to reduce administrative burden, cut millions in operational waste, and improve the quality of clinical care delivered to patients, raised $6.5 million in Seed funding.
ManchesterStory led the investment round with participation from Benhamou Global Ventures (BGV) and Arka Venture Labs.
With the fresh funds, XCaliber Health plans to accelerate rollout of its agentic AI operating system which is already serving many health systems, provider groups, and digital health partners in the U.S.
Health systems, provider groups, and digital health partners use XCaliber to replace manual, fragmented workflows, from prescription refill and referral coordination to lab notifications and care gap management, with autonomous execution and humans in control of every critical decision.
XCaliber Health platform acts as a specialized, AI-driven assistant rather than just a traditional billing or scheduling software, processing more than eight million chart updates and generating more than 160,000 EHR updates daily across more than 700,000 unique patients.
“Healthcare does not need more disconnected point solutions. It needs a system that can coordinate work across all of them and take the administrative burden off clinical and operational teams,” said Prakash Khot, co-founder and CEO of XCaliber.
“That is where XCaliber is focused. We are helping healthcare organizations move beyond manual work toward automated workflows that reduce costs, accelerate care delivery, and give clinical teams back the time to focus on patients. We’re honored to be backed by investors who believe in our mission to fundamentally reshape how healthcare operates,” added Prakash Khot.
“We invest in companies that move beyond pilots and demonstrate real adoption and change in the market. XCaliber is the perfect example of this,” said Matt Kinley, Founding Partner at ManchesterStory.
Digital health companies, including AI-powered healthcare workflow automation software startups, have secured more than $180 billion in funding to date, according to our recent 2026 Funding Database.
The funding activity is mainly driven by AI-driven digital health startups in 2026. Notable recent funding rounds include:
- Magicare AI (formerly Exponential), a developer of an agentic operating software system for post‑acute care providers, raised $3.6 million in a pre-seed funding round led by Mana Ventures.
- DEPTH Health, a developer of personalized, clinically guided, and AI-driven patient flow optimization solutions, raised $1 million in a Seed funding round from Green Harvest Capital Industries (GHC Industries), a minority-owned private equity firm with over $500 million in assets under ownership.
- Photon (Photon Health), a developer of the end-to-end AI-powered digital prescription infrastructure for modern healthcare, raised $16 million in a Series A round.
- Enzo Health, a provider of an AI-driven platform for home health and post-acute care providers, raised $20 million in a Series A funding round, bringing its funding to $26 million to date.